MICROSENS SEPRION PROTEIN AGGREGATION PRODUCTS
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| CalBioreagents is now the North American distributor for the Microsens Seprion technology product line.
Microsens Biotechnologies has developed synthetic ligand-based diagnostics for the rapid and sensitive detection of Transmlssible Spongiform Encephalopathies (TSEs) and other related protein aggregation diseases, such as Alzheimer's Disease and Parkinson's Disease - collectively known as the "Protein Conformation Disorders", or the “Protein Aggregation Diseases”.
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Seprion ligands selectively bind to protein aggregates and can be used to separate protein aggregates from non-aggregated protein. The ligands can be bound to magnetic beads (PAD-Beads) to selectively remove aggregated proteins from solution for further assay by commercial EIA, in-house EIA, or Western Blot. Alternatively, the Seprion ligand can be bound to a plate and can be used in a sandwich EIA to directly detect a specific protein with an appropriate labeled antibody.
In the diagram on the right, the ligand (represented by a spring) is bound to a plate surface. This selectively binds protein aggregates (yellow aggregate) and is detected with an appropriate labeled antibody (red).
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| Seprion Ligand EIA |
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PAD-BEADS KIT
PAD-Beads are a unique tool that can be used to separate abnormal proteins present in many types of Protein Aggregation Diseases from the normal unaggregated protein. This ability to easily and efficiently separate the abnormal from normal protein facilitates research on Protein Aggregation Diseases. Research applications include the study and monitoring of Protein Aggregation Diseases in human and animal samples and drug screening in vitro and in vivo.
PAD-Beads are a front-end separation technique that can be combined with a back-end protein-specific commercial or in-house ELISA detection to enable the specific detection of abnormal aggregated proteins. PAD-Beads can also be used as a sample preparation step prior to performing Western Blot techniques. PAD-Beads are intended
To date PAD-Beads have been demonstrated to work with β-amyloid, tau, α-synuclein, huntingtin and prion protein.
DOWNLOAD A PAD-BEADS FLYER
DOWNLOAD A PAD-BEADS PRODUCT MANUAL
FOR RESEARCH USE ONLY
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| PAD BEADS KIT |
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| PAD BEADS KIT CONTENTS |
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CREUTZFELDT JAKOB EIA KIT
96 well CJD EIA Test Kit
The Creutzfeldt-Jakob Disease (CJD) Abnormal Prion Protein Test Kit is an antigen-capture enzyme immunoassay (EIA) for detection of the abnormal conformer of the prion protein (PrPCJD) in brain and lymphoid tissues from individuals affected by Creutzfeldt-Jakob Disease (CJD). It is designed to rapidly identify samples containing disease-associated PrPCJD with minimal sample handling, and can be automated for high throughput applications.
DOWNLOAD A CJD-EIA KIT FLYER
DOWNLOAD A CJD-EIA PRODUCT MANUAL
FOR RESEARCH USE ONLY
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| CJD-EIA KIT |
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| CJD-EIA KIT CONTENTS |
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PRODUCTS IN DEVELOPMENT
SEPRION ALZHEIMER'S DETECTION EIA KIT
SEPRION PARKINSON'S DETECTION EIA KIT
SEPRION HUNTINGTON'S DETECTION EIA KIT
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